1-(2,4,5-Trimethylphenyl)piperazine → HCID 71252812, compound

HRID 2411609Notes

Reaction equation

HRID 2411609 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[CH3:19][C:20]1[CH:25]=[C:24]([CH3:26])[C:23]([CH3:27])=[CH:22][C:21]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:8]=[CH:9][C:10]([C:11]([N:31]2[CH2:32][CH2:33][N:28]([C:21]3[CH:22]=[C:23]([CH3:27])[C:24]([CH3:26])=[CH:25][C:20]=3[CH3:19])[CH2:29][CH2:30]2)=[O:13])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 27608211-(2,4,5-Trimethylphenyl)piperazineHCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

Product 1

HCID 71252812HCID 71252812, compoundYield 70.9%

Procedure

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(2,4,5-trimethylphenyl)piperazine (249 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (337 mg) was obtained.

Sources & evidence

ORD record
ord-b069a1a06fe4473ca1dcb01c7ab9b7ee
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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