5-Methyl-6-(piperazin-1-yl)nicotinonitrile → HCID 71252320, compound

HRID 2411628Notes

Reaction equation

HRID 2411628 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]([C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:9])[CH3:8].[CH3:20][C:21]1[C:22]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[N:23][CH:24]=[C:25]([CH:28]=1)[C:26]#[N:27]>>[O:19]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]([C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:22]3[C:21]([CH3:20])=[CH:28][C:25]([C:26]#[N:27])=[CH:24][N:23]=3)[CH2:30][CH2:31]2)=[O:16])=[CH:17][CH:18]=1)([CH3:8])[CH3:9]

Participants

3

Reactant 2

HCID 673812745-Methyl-6-(piperazin-1-yl)nicotinonitrileHCID 71251965HCID 71251965, compound

Product 1

HCID 71252320HCID 71252320, compoundYield 86.5%

Procedure

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-methylethyl]benzoic acid (100 mg) described in Preparation Example 39 and 5-methyl-6-(piperazin-1-yl)nicotinonitrile (71 mg) described in Preparation Example 103 and by the reaction and treatment in the same manner as in Example 87, the title compound (142 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 103 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-b2f5d22df5834c9d94fd3ed571da540e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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