5-Methyl-6-(piperazin-1-yl)nicotinonitrile → 6-(4-{4-[1-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoyl}piperazin-1-yl)-5-methylnicotinonitrile

Participants

Reaction Steps

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-methylethyl]benzoic acid (100 mg) described in Preparation Example 39 and 5-methyl-6-(piperazin-1-yl)nicotinonitrile (71 mg) described in Preparation Example 103 and by the reaction and treatment in the same manner as in Example 87, the title compound (142 mg) was obtained.

Provenance & Evidence