HCID 71251965, compound → 2-(4-{4-[1-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoyl}piperazin-1-yl)-5-methylnicotinonitrile

HRID 2411630Notes

Reaction equation

HRID 2411630 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]([C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:9])[CH3:8].[C:20]([C:22]1[C:23]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[N:24][CH:25]=[C:26]([CH3:28])[CH:27]=1)#[N:21]>>[O:19]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]([C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:23]3[N:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:22]=3[C:20]#[N:21])[CH2:30][CH2:31]2)=[O:16])=[CH:17][CH:18]=1)([CH3:8])[CH3:9]

Participants

3

Reactant 2

HCID 71251965HCID 71251965, compoundHCID 712522894-(3-Cyano-5-methylpyridin-2-yl)piperazine

Product 1

HCID 712518572-(4-{4-[1-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoyl}piperazin-1-yl)-5-methylnicotinonitrileYield 79.7%

Procedure

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-methylethyl]benzoic acid (100 mg) described in Preparation Example 39 and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (51 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Example 87, the title compound (94 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 107 and by the reaction and treatment in the same manner as in Example 87

Sources & evidence

ORD record
ord-96be8cf092f04baf9533a85385219581
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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