4-[1-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoic acid → 2-(4-{4-[1-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoyl}piperazin-1-yl)-5-methylnicotinonitrile

Participants

Reaction Steps

Using 4-[1-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-methylethyl]benzoic acid (100 mg) described in Preparation Example 39 and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (51 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Example 87, the title compound (94 mg) was obtained.

Provenance & Evidence