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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411631Generated: November 3, 2026

1,3-Propanesultam → 2-[4-[6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridine-3-carbonyl]piperazin-1-yl]-5-methylnicotinonitrile

https://huagongshe.com/reaction/2411631

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-PropanesultamHCID 642157—
Reactant2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrileHCID 86676764—
Product2-[4-[6-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)pyridine-3-carbonyl]piperazin-1-yl]-5-methylnicotinonitrileHCID 7125209368.8%

Reaction Steps

Using 2-[4-(6-bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile (150 mg) described in Preparation Example 184 and isothiazolidine 1,1-dioxide (71 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (114 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-d4b8ffd1c08543398996c89ba1dc4fc2
Source noteuspto-grants-2014_08