1,3-Propanesultam → HCID 71252747, compound

HRID 2411636Notes

Reaction equation

HRID 2411636 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:19]=3[CH3:25])[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[S:26]1(=[O:32])(=[O:31])[CH2:30][CH2:29][CH2:28][NH:27]1>>[CH3:25][C:19]1[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:18]=1[N:15]1[CH2:16][CH2:17][N:12]([C:10]([C:5]2[CH:4]=[CH:3][C:2]([N:27]3[CH2:28][CH2:29][CH2:30][S:26]3(=[O:32])=[O:31])=[CH:9][C:6]=2[C:7]#[N:8])=[O:11])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71251979HCID 71251979, compound

Product 1

HCID 71252747HCID 71252747, compoundYield 91.8%

Procedure

Using 5-bromo-2-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]benzonitrile (797 mg) described in Preparation Example 188 and isothiazolidine 1,1-dioxide (315 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (806 mg) was obtained.

Sources & evidence

ORD record
ord-316c0bfb0ed8407caa7e993c14f1cf37
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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