2-Pyrrolidone → HCID 71251878, compound

HRID 2411649Notes

Reaction equation

HRID 2411649 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([S:30]([CH3:33])(=[O:32])=[O:31])[CH:9]=1>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:11]3[CH:12]=[CH:13][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[CH:9][C:10]=3[S:30]([CH3:33])(=[O:32])=[O:31])=[O:15])[CH2:17][CH2:18]2)=[N:23][CH:24]=[C:25]([CH3:29])[CH:26]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484505(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71251878HCID 71251878, compoundYield 32.3%

Procedure

Using pyrrolidin-2-one (119 mg) and (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (664 mg) described in Preparation Example 112 and by the reaction and treatment in the same manner as in Example 1, the title compound (206 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 112 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-a371c5f9981c4f2e9d44a3bd04dd2fe9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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