2-Pyrrolidone → 1-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one

HRID 2411655Notes

Reaction equation

HRID 2411655 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][CH:19]([C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([C:22]([CH:19]2[CH2:18][CH2:17][N:16]([C:14]([C:11]3[CH:10]=[CH:9][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[N:13][CH:12]=3)=[O:15])[CH2:21][CH2:20]2)=[O:30])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484839(6-Bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone

Product 1

HCID 712524191-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-oneYield 50.7%

Procedure

Using pyrrolidin-2-one (102 mg) and (6-bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (408 mg) described in Preparation Example 190 and by the reaction and treatment in the same manner as in Example 1, the title compound (209 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 190 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-7865e164fb3a4aba8eef7754b1dfb96a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…