HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 1-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | (6-Bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone | HCID 58484839 | — |
| Product | 1-{5-[4-(4-Chlorobenzoyl)piperidine-1-carbonyl]pyridin-2-yl}pyrrolidin-2-one | HCID 71252419 | 50.7% |
Reaction Steps
Using pyrrolidin-2-one (102 mg) and (6-bromopyridin-3-yl)[4-(4-chlorobenzoyl)piperidin-1-yl]methanone (408 mg) described in Preparation Example 190 and by the reaction and treatment in the same manner as in Example 1, the title compound (209 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7865e164fb3a4aba8eef7754b1dfb96a |
| Source note | uspto-grants-2014_08 |