2-Pyrrolidone → 1-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}pyrrolidin-2-one

HRID 2411666Notes

Reaction equation

HRID 2411666 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH:7]1([C:10]2[C:11]([N:19]3[CH2:24][CH2:23][N:22]([C:25]([C:27]4[CH:32]=[CH:31][C:30](I)=[CH:29][C:28]=4[F:34])=[O:26])[CH2:21][CH2:20]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:9][CH2:8]1>>[CH:7]1([C:10]2[C:11]([N:19]3[CH2:20][CH2:21][N:22]([C:25]([C:27]4[CH:32]=[CH:31][C:30]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[CH:29][C:28]=4[F:34])=[O:26])[CH2:23][CH2:24]3)=[N:12][CH:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 71251940HCID 71251940, compound

Product 1

HCID 712519211-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}pyrrolidin-2-oneYield 63%

Procedure

Using pyrrolidin-2-one (35 mg) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone (200 mg) described in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1, the title compound (115 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-23480f00fb4a4ae6a90d7799bb0c4de5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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