HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 1-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | HCID 71251940 | HCID 71251940 | — |
| Product | 1-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}pyrrolidin-2-one | HCID 71251921 | 63% |
Reaction Steps
Using pyrrolidin-2-one (35 mg) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](2-fluoro-4-iodophenyl)methanone (200 mg) described in Preparation Example 164 and by the reaction and treatment in the same manner as in Example 1, the title compound (115 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-23480f00fb4a4ae6a90d7799bb0c4de5 |
| Source note | uspto-grants-2014_08 |