(S)-5-(Hydroxymethyl)-2-pyrrolidinone → HCID 71252589, compound

HRID 2411682Notes

Reaction equation

HRID 2411682 reaction equation
[OH:1][CH2:2][C@H:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.I[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1>>[OH:1][CH2:2][C@H:3]1[N:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([N:18]3[CH2:23][CH2:22][N:21]([C:24]4[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[C:26]([CH3:32])[N:25]=4)[CH2:20][CH2:19]3)=[O:17])=[CH:12][CH:11]=2)[C:6](=[O:8])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 643511(S)-5-(Hydroxymethyl)-2-pyrrolidinoneHCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252589HCID 71252589, compound

Procedure

Using (S)-5-hydroxymethylpyrrolidin-2-one and (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (871 mg) described in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 1, the title compound (348 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 120 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-22d2b08294194230b8283aa2b4509fc3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…