2-Pyrrolidone → HCID 71252636, compound

HRID 2411684Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH:7]1([C:10]2[CH:11]=[C:12]([CH3:31])[C:13]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([C:24]4[CH:29]=[CH:28][C:27](I)=[CH:26][CH:25]=4)=[O:23])[CH2:18][CH2:17]3)=[N:14][CH:15]=2)[CH2:9][CH2:8]1>>[CH:7]1([C:10]2[CH:11]=[C:12]([CH3:31])[C:13]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([C:24]4[CH:29]=[CH:28][C:27]([N:1]5[CH2:5][CH2:4][CH2:3][C:2]5=[O:6])=[CH:26][CH:25]=4)=[O:23])[CH2:18][CH2:17]3)=[N:14][CH:15]=2)[CH2:8][CH2:9]1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 58484841[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252636HCID 71252636, compoundYield 60.9%

Procedure

Using pyrrolidin-2-one (94 mg) and [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (447 mg) described in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 1, the title compound (246 mg) was obtained.

Workup

customdescribed in Preparation Example 117 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-a0ad17524b794dd79ef293ab8290c4a6
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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