2-Pyrrolidone → HCID 71252958, compound

HRID 2411690Notes

Reaction equation

HRID 2411690 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH2:29][CH3:30])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1>>[CH2:29]([C:25]1[CH:26]=[C:27]([CH3:28])[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:11]3[CH:10]=[CH:9][C:8]([N:1]4[CH2:5][CH2:4][CH2:3][C:2]4=[O:6])=[N:13][CH:12]=3)=[O:15])[CH2:17][CH2:18]2)=[N:23][CH:24]=1)[CH3:30]

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 58484652(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252958HCID 71252958, compoundYield 55.9%

Procedure

Using pyrrolidin-2-one (49 mg) and (6-bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (200 mg) described in Preparation Example 145 and by the reaction and treatment in the same manner as in Example 1, the title compound (113 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 145 and by the reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-16821c6e55a644b4a3d9acf1d51b83fe
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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