5-(Hydroxymethyl)pyrrolidin-2-one → HCID 71252133, compound

HRID 2411737Notes

Reaction equation

HRID 2411737 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH3:24])[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:25])[CH:3]=1.[OH:26][CH2:27][CH:28]1[NH:32][C:31](=[O:33])[CH2:30][CH2:29]1>>[CH3:24][C:18]1[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:17]=1[N:14]1[CH2:15][CH2:16][N:11]([C:9]([C:5]2[C:6]([F:8])=[CH:7][C:2]([N:32]3[C@H:28]([CH2:27][OH:26])[CH2:29][CH2:30][C:31]3=[O:33])=[CH:3][C:4]=2[F:25])=[O:10])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 5583595-(Hydroxymethyl)pyrrolidin-2-oneHCID 58484529HCID 58484529, compound

Product 1

HCID 71252133HCID 71252133, compoundYield 15%

Procedure

Using (4-bromo-2,6-difluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (819 mg) described in Preparation Example 109 and 5-hydroxymethylpyrrolidin-2-one (230 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (133 mg) was obtained.

Sources & evidence

ORD record
ord-367432373b4e423b810e6c56b8d5fa84
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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