Benzyl Bromide → HCID 71252798, compound

HRID 2411764Notes

Reaction equation

HRID 2411764 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:27][CH2:26][NH:25][C:24]3=[O:28])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[CH2:29](Br)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:29]([N:25]1[CH2:26][CH2:27][N:23]([C:20]2[CH:21]=[CH:22][C:17]([C:15]([N:12]3[CH2:13][CH2:14][N:9]([C:3]4[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=4[CH3:1])[CH2:10][CH2:11]3)=[O:16])=[CH:18][CH:19]=2)[C:24]1=[O:28])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 71252851HCID 71252851, compound

Product 1

HCID 71252798HCID 71252798, compound

Procedure

Using 1-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (100 mg) described in Example 401 and benzyl bromide (35 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (63 mg) was obtained.

Sources & evidence

ORD record
ord-c7bd49b32c3a42238ee4a3326bef9463
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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