Iodoethane → HCID 59586243, compound

HRID 241177Notes

Reaction equation

HRID 241177 reaction equation
[CH2:1]([NH:3][C:4]1[NH:8][C:7]2[CH:9]=[C:10]([C:13]3[CH:14]=[CH:15][C:16]4[O:22][CH2:21][CH2:20][N:19]([C:23]5[C:32]6[C:27](=[CH:28][C:29]([OH:33])=[CH:30][CH:31]=6)[N:26]=[C:25]([CH3:34])[N:24]=5)[CH2:18][C:17]=4[CH:35]=3)[CH:11]=[CH:12][C:6]=2[N:5]=1)[CH3:2].[CH2:36](I)[CH3:37]>>[CH2:1]([NH:3][C:4]1[NH:8][C:7]2[CH:9]=[C:10]([C:13]3[CH:14]=[CH:15][C:16]4[O:22][CH2:21][CH2:20][N:19]([C:23]5[C:32]6[C:27](=[CH:28][C:29]([O:33][CH2:36][CH3:37])=[CH:30][CH:31]=6)[N:26]=[C:25]([CH3:34])[N:24]=5)[CH2:18][C:17]=4[CH:35]=3)[CH:11]=[CH:12][C:6]=2[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 136378543HCID 136378543, compound

Product 1

HCID 59586243HCID 59586243, compound

Procedure

Prepared according to the method of example 10 using 4-{7-[2-(ethylamino)-1H-benzimidazol-6-yl]-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl}-2-methylquinazolin-7-ol (example 11) and ethyl iodide in step 2. 1H NMR (400 MHz, DMSO-d6) δ 10.36 (s, 1H), 7.91-7.82 (m, 1H), 7.63 (dd, 1H), 7.52-7.36 (m, 2H), 7.26-7.13 (m, 2H), 6.99 (dd, 1H), 6.94-6.86 (m, 2H), 6.70 (q, 1H), 4.96 (s, 2H), 4.45-4.35 (m, 2H), 4.16-3.98 (m, 4H), 3.46-3.36 (m, 2H), 2.44-2.37 (m, 3H), 1.28-1.17 (m, 6H); MS (EI) for C29H30N6O2: 495 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0ea59ad196c040d1be207f5f0e295c5c
Source dataset
uspto-grants-2014_02
Patent number
US08648066B2

Reaction notes

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