反应详情

3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (105 mg) described in Example 420 was dissolved in dichloromethane (1 mL), trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature overnight. The solvent was evaporated from the reaction mixture, 5% aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with chloroform/methanol (10/1). The organic layer was dried over sodium sulfate, and the solvent was evaporated. The obtained residue was suspension washing with IPE to give the title compound (86 mg).

1. customThe solvent was evaporated from the reaction mixture, 5% aqueous sodium hydrogen carbonate solution
2. additionwas added
3. extractionthe mixture was extracted with chloroform/methanol (10/1)
4. dry with materialThe organic layer was dried over sodium sulfate
5. customthe solvent was evaporated
6. washwashing with IPE