N-Acetylimidazolidinone → HCID 71252212, compound

HRID 2411791Notes

Reaction equation

HRID 2411791 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH:25]4[CH2:27][CH2:26]4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[C:28]([N:31]1[CH2:35][CH2:34][NH:33][C:32]1=[O:36])(=[O:30])[CH3:29]>>[C:28]([N:31]1[CH2:35][CH2:34][N:33]([C:2]2[CH:3]=[CH:4][C:5]([C:10]([N:12]3[CH2:17][CH2:16][N:15]([C:18]4[C:23]([CH3:24])=[CH:22][C:21]([CH:25]5[CH2:27][CH2:26]5)=[CH:20][N:19]=4)[CH2:14][CH2:13]3)=[O:11])=[C:6]([CH:9]=2)[C:7]#[N:8])[C:32]1=[O:36])(=[O:30])[CH3:29]

Participants

3

Reactant 2

HCID 79350N-AcetylimidazolidinoneHCID 584845735-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

Product 1

HCID 71252212HCID 71252212, compoundYield 41.9%

Procedure

Using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (1.06 g) described in Preparation Example 189 and 1-acetylimidazolidin-2-one (384 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (494 mg) was obtained.

Sources & evidence

ORD record
ord-5ac41636245b4496be2f3ea48dec02fb
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…