2-Bromoethyl methyl ether → HCID 71252547, compound

HRID 2411794Notes

Reaction equation

HRID 2411794 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:24]=[CH:23][C:22]([N:25]4[CH2:29][CH2:28][NH:27][C:26]4=[O:30])=[CH:21][C:18]=3[C:19]#[N:20])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.Br[CH2:32][CH2:33][O:34][CH3:35]>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:24]=[CH:23][C:22]([N:25]4[CH2:29][CH2:28][N:27]([CH2:32][CH2:33][O:34][CH3:35])[C:26]4=[O:30])=[CH:21][C:18]=3[C:19]#[N:20])=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 71252730HCID 71252730, compound

Product 1

HCID 71252547HCID 71252547, compoundYield 73.9%

Procedure

Using 2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxoimidazolidin-1-yl)benzonitrile (399 mg) described in Example 434 and 1-bromo-2-methoxyethane (165 mg) and by the reaction and treatment in the same manner as in Example 36, the title compound (337 mg) was obtained.

Sources & evidence

ORD record
ord-eee3d87933db4d41bd366c8445b22b39
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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