2-Azetidinone → HCID 71252114, compound

HRID 2411835Notes

Reaction equation

HRID 2411835 reaction equation
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=3)[CH2:13][CH2:12]2)=[O:10])=[C:4]([F:25])[CH:3]=1.[NH:26]1[CH2:29][CH2:28][C:27]1=[O:30]>>[CH3:23][C:22]1[C:17]([N:14]2[CH2:15][CH2:16][N:11]([C:9]([C:5]3[C:6]([F:8])=[CH:7][C:2]([N:26]4[CH2:29][CH2:28][C:27]4=[O:30])=[CH:3][C:4]=3[F:25])=[O:10])[CH2:12][CH2:13]2)=[N:18][CH:19]=[C:20]([CH3:24])[CH:21]=1

Participants

3

Reactant 2

HCID 1367212-AzetidinoneHCID 58484761(4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252114HCID 71252114, compoundYield 54.7%

Procedure

Using (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (410 mg) described in Preparation Example 111 and 2-azetidinone (75 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (219 mg) was obtained.

Sources & evidence

ORD record
ord-f9a23722af9b44da9bfe8a51a6fabd13
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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