4-(Methylsulfonamido)benzoic acid → N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]phenyl}methanesulfonamide

HRID 2411842Notes

Reaction equation

HRID 2411842 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])=[CH:19][CH:18]=1>>[CH3:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]([CH:25]2[CH2:26][CH2:27][N:28]([C:10]([C:9]3[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:14][CH:13]=3)=[O:12])[CH2:29][CH2:30]2)=[O:24])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2506534-(Methylsulfonamido)benzoic acidHCID 27408174-(4-Methylbenzoyl)piperidine hydrochloride

Product 1

HCID 71252640N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]phenyl}methanesulfonamideYield 14.6%

Procedure

Using 4-methanesulfonylaminobenzoic acid (136 mg) and (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (152 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (37 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 86

Sources & evidence

ORD record
ord-0dc2197c7baa4f018c7fd80ce95cdeea
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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