N-Methylmethanesulfonamide → HCID 71252042, compound

HRID 2411843Notes

Reaction equation

HRID 2411843 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:24])[CH:3]=1.[CH3:25][NH:26][S:27]([CH3:30])(=[O:29])=[O:28]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:26]([CH3:25])[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:3][C:4]=3[F:24])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 97632N-MethylmethanesulfonamideHCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252042HCID 71252042, compoundYield 89.5%

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (624 mg) described in Preparation Example 114 and N-methylmethanesulfonamide (349 mg) and by the reaction and treatment in the same manner as in Example 4, the title compound (599 mg) was obtained.

Sources & evidence

ORD record
ord-a73b88fabaf14b4c8ad1ce046dac07c9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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