(4-Bromo-2-fluorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252068, compound

HRID 2411880Notes

Reaction equation

HRID 2411880 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C4CC4)=CN=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH:43]1([C:46]2[CH:47]=[C:48]([CH3:83])[C:49]([N:52]3[CH2:57][CH2:56][N:55]([C:58]([C:60]4[CH:65]=[CH:64][C:63]([N:66]5[CH:70]([CH3:71])[CH2:69][N:68](CC6C=CC(OC)=CC=6)[C:67]5=[O:81])=[CH:62][C:61]=4[F:82])=[O:59])[CH2:54][CH2:53]3)=[N:50][CH:51]=2)[CH2:45][CH2:44]1>>[CH:43]1([C:46]2[CH:47]=[C:48]([CH3:83])[C:49]([N:52]3[CH2:53][CH2:54][N:55]([C:58]([C:60]4[CH:65]=[CH:64][C:63]([N:66]5[CH:70]([CH3:71])[CH2:69][NH:68][C:67]5=[O:81])=[CH:62][C:61]=4[F:82])=[O:59])[CH2:56][CH2:57]3)=[N:50][CH:51]=2)[CH2:44][CH2:45]1

Participants

4

Reactant 3

HCID 58484842(4-Bromo-2-fluorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-oneHCID 71252942HCID 71252942, compound

Product 1

HCID 71252068HCID 71252068, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (167 mg) described in Preparation Example 121 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (109 mg) was obtained via 3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-537de29dc89b444f944e51d49e96832e
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…