(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252015, compound

HRID 2411898Notes

Reaction equation

HRID 2411898 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=C(C)N=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2C(=O)C(C)NC2=O)=CC=1.[F:43][C:44]1[CH:45]=[C:46]([N:67]2[CH:71]([CH3:72])[C:70](=[O:73])[N:69](CC3C=CC(OC)=CC=3)[C:68]2=[O:83])[CH:47]=[CH:48][C:49]=1[C:50]([N:52]1[CH2:57][CH2:56][N:55]([C:58]2[C:63]([CH3:64])=[CH:62][C:61]([CH3:65])=[C:60]([CH3:66])[N:59]=2)[CH2:54][CH2:53]1)=[O:51]>>[F:43][C:44]1[CH:45]=[C:46]([N:67]2[CH:71]([CH3:72])[C:70](=[O:73])[NH:69][C:68]2=[O:83])[CH:47]=[CH:48][C:49]=1[C:50]([N:52]1[CH2:57][CH2:56][N:55]([C:58]2[C:63]([CH3:64])=[CH:62][C:61]([CH3:65])=[C:60]([CH3:66])[N:59]=2)[CH2:54][CH2:53]1)=[O:51]

Participants

4

Reactant 3

HCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 683283563-(4-Methoxybenzyl)-5-methylimidazolidine-2,4-dioneHCID 71252342HCID 71252342, compound

Product 1

HCID 71252015HCID 71252015, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (325 mg) described in Preparation Example 128 and 3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione (187 mg) described in Preparation Example 51 and by the reaction and treatment in the same manner as in Example 508, the title compound (169 mg) was obtained via 1-{3-fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)-5-methylimidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 51 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-bffdb2eb8a1048f8a1afa7f0f366a6f7
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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