Ethanol hydrochloride → HCID 71252528, compound

HRID 2411901Notes

Reaction equation

HRID 2411901 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][NH:25][C:24]4=[O:28])=[CH:19][C:18]=3[F:29])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[ClH:30].C(O)C>C(Cl)(Cl)Cl.CO>[ClH:30].[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][NH:25][C:24]4=[O:28])=[CH:19][C:18]=3[F:29])=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 54675508HCID 54675508, compound

Product 1

HCID 71252528HCID 71252528, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}imidazolidin-2-one (840 mg) described in Example 416 was dissolved in chloroform/methanol, 2N hydrogen chloride/ethanol solution was added, and the solvent was evaporated under reduced pressure. The obtained residue was suspension washed with ethyl acetate to give the title compound (909 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-0441c7e5aac8440bb8783c5cbe9bea55
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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