HCID 21700179, compound → HCID 71251908, compound

HRID 2411923Notes

Reaction equation

HRID 2411923 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2C(=O)C(C)(C)NC2=O)=CC=1.[CH3:43][C:44]1[C:45]([N:51]2[CH2:56][CH2:55][N:54]([C:57]([C:59]3[CH:64]=[CH:63][C:62]([N:65]4[C:69]([CH3:71])([CH3:70])[C:68](=[O:72])[N:67](CC5C=CC(OC)=CC=5)[C:66]4=[O:82])=[CH:61][C:60]=3[F:83])=[O:58])[CH2:53][CH2:52]2)=[N:46][CH:47]=[C:48]([CH3:50])[CH:49]=1>>[CH3:43][C:44]1[C:45]([N:51]2[CH2:52][CH2:53][N:54]([C:57]([C:59]3[CH:64]=[CH:63][C:62]([N:65]4[C:69]([CH3:71])([CH3:70])[C:68](=[O:72])[NH:67][C:66]4=[O:82])=[CH:61][C:60]=3[F:83])=[O:58])[CH2:55][CH2:56]2)=[N:46][CH:47]=[C:48]([CH3:50])[CH:49]=1

Participants

4

Reactant 3

HCID 21700179HCID 21700179, compoundHCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252197HCID 71252197, compound

Product 1

HCID 71251908HCID 71251908, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (235 mg) described in Preparation Example 114 and 3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione (149 mg) described in Preparation Example 53 and by the reaction and treatment in the same manner as in Example 508, the title compound (130 mg) was obtained via 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 53 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-40d0839b9f4e4f4b989a21d4f2a497b5
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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