2,4-Imidazolidinedione, 3-methyl- → HCID 71251872, compound

HRID 2411934Notes

Reaction equation

HRID 2411934 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH2:23][CH3:24])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:25])[CH:3]=1.[CH3:26][N:27]1[C:31](=[O:32])[CH2:30][NH:29][C:28]1=[O:33]>>[CH2:23]([C:19]1[CH:20]=[C:21]([CH3:22])[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([N:29]4[CH2:30][C:31](=[O:32])[N:27]([CH3:26])[C:28]4=[O:33])=[CH:3][C:4]=3[F:25])=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=1)[CH3:24]

Participants

3

Reactant 2

HCID 1388512,4-Imidazolidinedione, 3-methyl-HCID 58484537(4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71251872HCID 71251872, compoundYield 65.2%

Procedure

Using (4-bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (163 mg) described in Preparation Example 211 and 3-methylimidazolidine-2,4-dione (68 mg) described in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536, the title compound (115 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536

Sources & evidence

ORD record
ord-446873959fb24e1884145dca72d4597a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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