Hydrogen chloride-ethyl acetate → HCID 86676790, compound

HRID 2411951Notes

Reaction equation

HRID 2411951 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[C:18]([CH3:30])=[CH:19][C:20]([N:23]4[CH2:27][CH2:26][N:25]([CH3:28])[C:24]4=[O:29])=[N:21][CH:22]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[ClH:31].[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[C:18]([CH3:30])=[CH:19][C:20]([N:23]4[CH2:27][CH2:26][N:25]([CH3:28])[C:24]4=[O:29])=[N:21][CH:22]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 71252593HCID 71252593, compound

Product 1

HCID 86676790HCID 86676790, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using (6-bromo-4-methylpyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (195 mg) described in Preparation Example 228 and 1-methylimidazolidin-2-one (75 mg) and by the reaction and treatment in the same manner as in Example 511, 1-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}-3-methylimidazolidin-2-one (160 mg) was obtained. The obtained 1-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}-3-methylimidazolidin-2-one (160 mg) was dissolved in ethyl acetate, 4N hydrogen chloride/ethyl acetate (0.2 mL) was added, and the precipitate was collected by filtration to give the title compound (98 mg).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-d46dca8ae7eb4cd2bd3d0f145cf3dee8
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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