1,3-Propanesultam → HCID 71252374, compound

HRID 2411992Notes

Reaction equation

HRID 2411992 reaction equation
C([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:32])(=O)C.[S:33]1(=[O:39])(=[O:38])[CH2:37][CH2:36][CH2:35][NH:34]1>>[CH3:30][C:29]1[C:24]([N:21]2[CH2:20][CH2:19][N:18]([C:16]([C:10]3[CH:11]=[CH:12][C:13]([N:34]4[CH2:35][CH2:36][CH2:37][S:33]4(=[O:39])=[O:38])=[CH:14][C:9]=3[N:6]3[CH2:7][CH2:8][NH:4][C:5]3=[O:32])=[O:17])[CH2:23][CH2:22]2)=[N:25][CH:26]=[C:27]([CH3:31])[CH:28]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 584846831-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one

Product 1

HCID 71252374HCID 71252374, compoundYield 28.1%

Procedure

Using 1-acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (117 mg) described in Preparation Example 234 and isothiazolidine 1,1-dioxide (47 mg) and by the reaction and treatment in the same manner as in Example 649, the title compound (36 mg) was obtained.

Sources & evidence

ORD record
ord-8237abfdff73470ba10c5c8cc82039ba
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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