2-Pyrrolidone → HCID 71252377, compound

HRID 2411994Notes

Reaction equation

C([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=O)C.[NH:35]1[CH2:39][CH2:38][CH2:37][C:36]1=[O:40]>>[CH:31]1([C:27]2[CH:28]=[C:29]([CH3:30])[C:24]([N:21]3[CH2:22][CH2:23][N:18]([C:16]([C:10]4[CH:11]=[CH:12][C:13]([N:35]5[CH2:39][CH2:38][CH2:37][C:36]5=[O:40])=[CH:14][C:9]=4[N:6]4[CH2:7][CH2:8][NH:4][C:5]4=[O:34])=[O:17])[CH2:19][CH2:20]3)=[N:25][CH:26]=2)[CH2:32][CH2:33]1

Participants

Reactant 2

HCID 120252-Pyrrolidone

HCID 58484546HCID 58484546, compound

Product 1

HCID 71252377HCID 71252377, compoundYield 44.8%

Procedure

Using 1-acetyl-3-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (165 mg) described in Preparation Example 236 and pyrrolidin-2-one (44 mg) and by the reaction and treatment in the same manner as in Example 649, the title compound (75 mg) was obtained.

Sources & evidence

ORD record: ord-94f0ac6ac7944fd9a806d20146e60171
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

Loading…