1-Methylimidazolidin-2-one → [2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2412001Notes

Reaction equation

HRID 2412001 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:26])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21](Br)=[CH:20][C:19]=4Br)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:27][N:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[CH3:27][N:28]1[CH2:32][CH2:31][N:30]([C:19]2[CH:20]=[C:21]([N:30]3[CH2:31][CH2:32][N:28]([CH3:27])[C:29]3=[O:33])[CH:22]=[CH:23][C:18]=2[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:7]3[C:6]([CH3:26])=[CH:5][C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:9][N:8]=3)[CH2:11][CH2:12]2)=[O:17])[C:29]1=[O:33]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71252039[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone

Product 1

HCID 71252105[2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 25.7%

Procedure

Using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone (238 mg) described in Preparation Example 238 and 1-methylimidazolidin-2-one (149 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (66 mg) was obtained.

Sources & evidence

ORD record
ord-030bc4bfb2054ec9b15b8d507e3421a3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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