HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylimidazolidin-2-one → [2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylimidazolidin-2-one | HCID 567600 | — |
| Reactant | [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone | HCID 71252039 | — |
| Product | [2,4-Bis(3-methyl-2-oxoimidazolidin-1-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 71252105 | 25.7% |
Reaction Steps
Using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](2,4-dibromophenyl)methanone (238 mg) described in Preparation Example 238 and 1-methylimidazolidin-2-one (149 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (66 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-030bc4bfb2054ec9b15b8d507e3421a3 |
| Source note | uspto-grants-2014_08 |