1,3-Propanesultam → HCID 71252531, compound

HRID 2412019Notes

Reaction equation

HRID 2412019 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[S:26]1(=[O:32])(=[O:31])[CH2:30][CH2:29][CH2:28][NH:27]1>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:4]=[N:3][C:2]([N:27]5[CH2:28][CH2:29][CH2:30][S:26]5(=[O:32])=[O:31])=[CH:7][N:6]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 86676769HCID 86676769, compound

Product 1

HCID 71252531HCID 71252531, compoundYield 66.1%

Procedure

Using (5-bromopyrazin-2-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 243 and isothiazolidine 1,1-dioxide (54 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (109 mg) was obtained.

Sources & evidence

ORD record
ord-0937a83bb8b14c92b0eeb4838c856819
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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