1,4-Butanesultam → HCID 71252008, compound

HRID 2412060Notes

Reaction equation

HRID 2412060 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[S:25]1(=[O:32])(=[O:31])[CH2:30][CH2:29][CH2:28][CH2:27][NH:26]1>>[O:31]=[S:25]1(=[O:32])[CH2:30][CH2:29][CH2:28][CH2:27][N:26]1[C:20]1[CH:21]=[CH:22][C:17]([C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[C:5]([CH3:24])=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=3)[CH2:10][CH2:11]2)=[O:16])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 3035081,4-ButanesultamHCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252008HCID 71252008, compoundYield 58.5%

Procedure

Using [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (348 mg) described in Preparation Example 133 and [1,2]thiazinane 1,1-dioxide (141 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (207 mg) was obtained.

Sources & evidence

ORD record
ord-13684c11031242cca1b59b2ea8fbbf52
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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