1,4-Butanesultam → HCID 71252924, compound

HRID 2412068Notes

Reaction equation

HRID 2412068 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH2:25][CH3:26])=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[S:27]1(=[O:34])(=[O:33])[CH2:32][CH2:31][CH2:30][CH2:29][NH:28]1>>[O:33]=[S:27]1(=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29][N:28]1[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH2:25][CH3:26])=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8]

Participants

3

Reactant 2

HCID 3035081,4-ButanesultamHCID 71252298HCID 71252298, compound

Product 1

HCID 71252924HCID 71252924, compoundYield 86.6%

Procedure

Using 5-bromo-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (827 mg) described in Preparation Example 246 and [1,2]thiazinane 1,1-dioxide (351 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (810 mg) was obtained.

Sources & evidence

ORD record
ord-4c4ddbfffa0d4a9ba4a4b68db59ff1ac
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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