Pyrrolidine → HCID 71251964, compound

HRID 2412088Notes

Reaction equation

C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[C:33]([CH3:39])[N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.N1C[CH2:51][CH2:50][CH2:49]1>>[O:21]=[S:17]1(=[O:22])[CH2:18][CH2:19][CH2:20][N:16]1[C:14]1[CH:13]=[CH:12][C:11]([C:23]([N:25]2[CH2:30][CH2:29][N:28]([C:31]3[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[C:33]([CH3:39])[N:32]=3)[CH2:27][CH2:26]2)=[O:24])=[C:10]([C:9]([N:8]2[CH2:6][CH2:51][CH2:50][CH2:49]2)=[O:40])[CH:15]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 71251970HCID 71251970, compound

Product 1

HCID 71251964HCID 71251964, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzamide (202 mg) described in Example 768 and pyrrolidine (30 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (127 mg) was obtained.

Sources & evidence

ORD record: ord-51352f2fb2134948a001ee8b07e68fbf
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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