HCID 71252189, compound → HCID 71252623, compound

HRID 2412089Notes

Reaction equation

HRID 2412089 reaction equation
C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C>O1CCCC1.CN>[O:22]=[S:17]1(=[O:21])[CH2:18][CH2:19][CH2:20][N:16]1[C:14]1[CH:13]=[CH:12][C:11]([C:23]([N:25]2[CH2:26][CH2:27][N:28]([C:31]3[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=3)[CH2:29][CH2:30]2)=[O:24])=[C:10]([CH:15]=1)[C:9]([NH:8][CH3:6])=[O:40]

Participants

3

Reactant 1

HCID 71252189HCID 71252189, compound

Product 1

HCID 71252623HCID 71252623, compoundYield 65.7%

Reagents, catalysts & solvents 1

HCID 66615946Methylamine tetrahydrofuranSolvent

Procedure

Using N,N-di-tert-butyloxycarbonyl-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzamide (202 mg) described in Example 785 and 2 mol/L methylamine tetrahydrofuran solution (180 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (96 mg) was obtained.

Sources & evidence

ORD record
ord-009927ad582f488db37c7bcb7b6f19f0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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