HCID 71252189, compound → HCID 71253194, compound

HRID 2412091Notes

Reaction equation

HRID 2412091 reaction equation
C(O[C:6]([N:8]([C:41](OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C>O1CCCC1.CNC>[O:22]=[S:17]1(=[O:21])[CH2:18][CH2:19][CH2:20][N:16]1[C:14]1[CH:13]=[CH:12][C:11]([C:23]([N:25]2[CH2:30][CH2:29][N:28]([C:31]3[C:36]([CH3:37])=[CH:35][C:34]([CH2:38][CH3:39])=[CH:33][N:32]=3)[CH2:27][CH2:26]2)=[O:24])=[C:10]([CH:15]=1)[C:9]([N:8]([CH3:41])[CH3:6])=[O:40]

Participants

3

Reactant 1

HCID 71252189HCID 71252189, compound

Product 1

HCID 71253194HCID 71253194, compoundYield 53.9%

Reagents, catalysts & solvents 1

HCID 22320367Dimethylamine tetrahydrofuranSolvent

Procedure

Using N,N-di-tert-butyloxycarbonyl-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzamide (202 mg) described in Example 785 and 2M dimethylamine tetrahydrofuran solution (180 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (81 mg) was obtained.

Sources & evidence

ORD record
ord-49574d12d1bf49fba2a9c7c6f6e477fe
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…