1-(3,5-Dimethylpyridin-2-yl)piperazine → 1-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-3,5-dimethylimidazolidine-2,4-dione

HRID 2412095Notes

Reaction equation

HRID 2412095 reaction equation
[CH3:1][N:2]1[C:6](=[O:7])[CH:5]([CH3:8])[N:4]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=O)=[C:11]([CH3:19])[N:10]=2)[C:3]1=[O:20].[CH3:21][C:22]1[C:23]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[N:24][CH:25]=[C:26]([CH3:28])[CH:27]=1>>[CH3:21][C:22]1[C:23]([N:29]2[CH2:30][CH2:31][N:32]([C:13]([C:12]3[CH:17]=[CH:18][C:9]([N:4]4[CH:5]([CH3:8])[C:6](=[O:7])[N:2]([CH3:1])[C:3]4=[O:20])=[N:10][C:11]=3[CH3:19])=[O:15])[CH2:33][CH2:34]2)=[N:24][CH:25]=[C:26]([CH3:28])[CH:27]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252642Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate

Product 1

HCID 712523791-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-3,5-dimethylimidazolidine-2,4-dioneYield 80.9%

Procedure

Using methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate (19 mg) described in Preparation Example 255 and 1-(3,5-dimethylpyridin-2-yl)piperazine (13 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (24 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-2686099e2e034cbdb8e755b9223751ba
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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