HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dimethylpyridin-2-yl)piperazine → 1-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-3,5-dimethylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine | HCID 58484496 | — |
| Reactant | Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate | HCID 71252642 | — |
| Product | 1-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-6-methylpyridin-2-yl}-3,5-dimethylimidazolidine-2,4-dione | HCID 71252379 | 80.9% |
Reaction Steps
Using methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate (19 mg) described in Preparation Example 255 and 1-(3,5-dimethylpyridin-2-yl)piperazine (13 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (24 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-2686099e2e034cbdb8e755b9223751ba |
| Source note | uspto-grants-2014_08 |