1,3-Propanesultam → HCID 71252106, compound

HRID 2412096Notes

Reaction equation

HRID 2412096 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])=[C:6]([N:8]2[CH2:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]2=[O:15])[CH:7]=1.[S:32]1(=[O:38])(=[O:37])[CH2:36][CH2:35][CH2:34][NH:33]1>>[CH3:30][C:29]1[C:24]([N:21]2[CH2:22][CH2:23][N:18]([C:16]([C:5]3[CH:4]=[CH:3][C:2]([N:33]4[CH2:34][CH2:35][CH2:36][S:32]4(=[O:38])=[O:37])=[CH:7][C:6]=3[N:8]3[CH2:12][C:11](=[O:13])[N:10]([CH3:14])[C:9]3=[O:15])=[O:17])[CH2:19][CH2:20]2)=[N:25][CH:26]=[C:27]([CH3:31])[CH:28]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 71253013HCID 71253013, compound

Product 1

HCID 71252106HCID 71252106, compoundYield 37.2%

Procedure

Using 1-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-methylimidazolidine-2,4-dione (149 mg) described in Preparation Example 256 and isothiazolidine 1,1-dioxide (61 mg) and by the reaction and treatment in the same manner as in Example 666, the title compound (66 mg) was obtained.

Sources & evidence

ORD record
ord-e1b9981728314ca291ac1cd5b0e879c4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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