3-Methoxybenzylamine → HCID 71252777, compound

HRID 2412104Notes

Reaction equation

C(OC([N:8]([C:39](OC(C)(C)C)=O)[C:9](=[O:38])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.[CH3:46][O:47][C:48]1[CH:49]=[C:50]([CH:53]=[CH:54][CH:55]=1)CN>>[CH3:36][C:35]1[C:30]([N:27]2[CH2:26][CH2:25][N:24]([C:22]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][C:17]4=[O:21])=[CH:15][C:10]=3[C:9]([NH:8][CH2:39][C:54]3[CH:53]=[CH:50][CH:49]=[C:48]([O:47][CH3:46])[CH:55]=3)=[O:38])=[O:23])[CH2:29][CH2:28]2)=[N:31][CH:32]=[C:33]([CH3:37])[CH:34]=1

Participants

Reactant 2

HCID 211563-Methoxybenzylamine

HCID 71252805HCID 71252805, compound

Product 1

HCID 71252777HCID 71252777, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (187 mg) described in Example 769 and 3-methoxybenzylamine (36 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (120 mg) was obtained.

Sources & evidence

ORD record: ord-93a088ab753b406b89bd270a671ebf9a
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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