Pyrrolidine → HCID 71252131, compound

HRID 2412109Notes

Reaction equation

C(OC([N:8]([C:40](OC(C)(C)C)=O)[C:9](=[O:39])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH2:37][CH3:38])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.N1C[CH2:50][CH2:49][CH2:48]1>>[CH2:37]([C:33]1[CH:34]=[C:35]([CH3:36])[C:30]([N:27]2[CH2:26][CH2:25][N:24]([C:22]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][C:17]4=[O:21])=[CH:15][C:10]=3[C:9]([N:8]3[CH2:40][CH2:50][CH2:49][CH2:48]3)=[O:39])=[O:23])[CH2:29][CH2:28]2)=[N:31][CH:32]=1)[CH3:38]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 71252122HCID 71252122, compound

Product 1

HCID 71252131HCID 71252131, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 809 and pyrrolidine (36 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (33 mg) was obtained.

Sources & evidence

ORD record: ord-30ae362f77da46119e740e9dcdf54e60
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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