Pyrrolidine → HCID 71252438, compound

HRID 2412113Notes

Reaction equation

C(O[C:6]([N:8]([C:41](OC(C)(C)C)=O)[C:9](=[O:40])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH:37]3[CH2:39][CH2:38]3)=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.N1CC[CH2:50][CH2:49]1>>[CH:37]1([C:33]2[CH:34]=[C:35]([CH3:36])[C:30]([N:27]3[CH2:28][CH2:29][N:24]([C:22]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][C:17]5=[O:21])=[CH:15][C:10]=4[C:9]([N:8]4[CH2:41][CH2:50][CH2:49][CH2:6]4)=[O:40])=[O:23])[CH2:25][CH2:26]3)=[N:31][CH:32]=2)[CH2:38][CH2:39]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 71252396HCID 71252396, compound

Product 1

HCID 71252438HCID 71252438, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (70 mg) described in Example 814 and pyrrolidine (36 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (45 mg) was obtained.

Sources & evidence

ORD record: ord-96794e9e929c4d13bc7c7032fd472af8
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

Loading…