2-Methoxyethylamine → HCID 71252516, compound

HRID 2412118Notes

Reaction equation

C(OC(N(C(OC(C)(C)C)=O)[C:9](=[O:38])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][C:17]2=[O:21])[CH:13]=[CH:12][C:11]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23])=O)(C)(C)C.[CH3:46][O:47][CH2:48][CH2:49][NH2:50]>>[CH3:36][C:35]1[C:30]([N:27]2[CH2:26][CH2:25][N:24]([C:22]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][C:17]4=[O:21])=[CH:15][C:10]=3[C:9]([NH:50][CH2:49][CH2:48][O:47][CH3:46])=[O:38])=[O:23])[CH2:29][CH2:28]2)=[N:31][CH:32]=[C:33]([CH3:37])[CH:34]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 71252805HCID 71252805, compound

Product 1

HCID 71252516HCID 71252516, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(2-oxopyrrolidin-1-yl)benzamide (150 mg) described in Example 769 and 2-methoxyethylamine (84 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (68 mg) was obtained.

Sources & evidence

ORD record: ord-0135865fbe2f4f3c948b6020af6d2919
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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