Pyrrolidine → HCID 71252415, compound

HRID 2412125Notes

Reaction equation

C(O[C:6]([N:8](C(OC(C)(C)C)=O)[C:9](=[O:41])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH:38]3[CH2:40][CH2:39]3)=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.N1C[CH2:52][CH2:51][CH2:50]1>>[CH:38]1([C:34]2[CH:35]=[C:36]([CH3:37])[C:31]([N:28]3[CH2:27][CH2:26][N:25]([C:23]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][S:17]5(=[O:22])=[O:21])=[CH:15][C:10]=4[C:9]([N:8]4[CH2:52][CH2:51][CH2:50][CH2:6]4)=[O:41])=[O:24])[CH2:30][CH2:29]3)=[N:32][CH:33]=2)[CH2:40][CH2:39]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 71252685HCID 71252685, compound

Product 1

HCID 71252415HCID 71252415, compound

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzamide (90 mg) described in Example 805 and pyrrolidine (13 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (59 mg) was obtained.

Sources & evidence

ORD record: ord-347d1b1ac30b49eb8b1754972a662731
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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