Dimethylamine tetrahydrofuran → HCID 71253196, compound

HRID 2412126Notes

Reaction equation

C(O[C:6]([N:8]([C:42](OC(C)(C)C)=O)[C:9](=[O:41])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH:38]3[CH2:40][CH2:39]3)=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C.O1CCCC1.CNC>>[CH:38]1([C:34]2[CH:35]=[C:36]([CH3:37])[C:31]([N:28]3[CH2:27][CH2:26][N:25]([C:23]([C:11]4[CH:12]=[CH:13][C:14]([N:16]5[CH2:20][CH2:19][CH2:18][S:17]5(=[O:22])=[O:21])=[CH:15][C:10]=4[C:9]([N:8]([CH3:42])[CH3:6])=[O:41])=[O:24])[CH2:30][CH2:29]3)=[N:32][CH:33]=2)[CH2:40][CH2:39]1

Participants

Reactant 2

HCID 22320367Dimethylamine tetrahydrofuran

HCID 71252685HCID 71252685, compound

Product 1

HCID 71253196HCID 71253196, compoundYield 54.8%

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzamide (100 mg) described in Example 805 and 2 mol/L dimethylamine tetrahydrofuran solution (88 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (41 mg) was obtained.

Sources & evidence

ORD record: ord-9a4aefedf1064c70a993f966891b8d81
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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