HCID 71252306, compound → HCID 71252462, compound

HRID 2412128Notes

Reaction equation

HRID 2412128 reaction equation
C(O[C:6]([N:8]([C:40](OC(C)(C)C)=O)[C:9](=[O:39])[C:10]1[CH:15]=[C:14]([N:16]2[CH2:20][CH2:19][CH2:18][S:17]2(=[O:22])=[O:21])[CH:13]=[CH:12][C:11]=1[C:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[C:36]([CH3:37])=[CH:35][C:34]([CH3:38])=[CH:33][N:32]=2)[CH2:27][CH2:26]1)=[O:24])=O)(C)(C)C>O1CCCC1.CNC>[CH3:37][C:36]1[C:31]([N:28]2[CH2:27][CH2:26][N:25]([C:23]([C:11]3[CH:12]=[CH:13][C:14]([N:16]4[CH2:20][CH2:19][CH2:18][S:17]4(=[O:21])=[O:22])=[CH:15][C:10]=3[C:9]([N:8]([CH3:40])[CH3:6])=[O:39])=[O:24])[CH2:30][CH2:29]2)=[N:32][CH:33]=[C:34]([CH3:38])[CH:35]=1

Participants

3

Reactant 1

HCID 71252306HCID 71252306, compound

Product 1

HCID 71252462HCID 71252462, compoundYield 45.9%

Reagents, catalysts & solvents 1

HCID 22320367Dimethylamine tetrahydrofuranSolvent

Procedure

Using N,N-di-tert-butyloxycarbonyl-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(1,1-dioxo-1λ6-isothiazolidin-2-yl)benzamide (115 mg) described in Example 808 and 2 mol/L dimethylamine tetrahydrofuran solution (105 μL) and by the reaction and treatment in the same manner as in Example 770, the title compound (39 mg) was obtained.

Sources & evidence

ORD record
ord-2b5a7a527a5c433296b25cce19ce0df4
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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